Unravelling the mechanism of dual-specificity GAPs
نویسندگان
چکیده
منابع مشابه
Unravelling the mechanism of dual-specificity GAPs.
The molecular mechanism by which dual-specificity RasGAPs of the Gap1 subfamily activate the GTP hydrolysis of both Rap and Ras is an unresolved phenomenon. RasGAPs and RapGAPs use different strategies to stimulate the GTPase reaction of their cognate G-proteins. RasGAPs contribute an arginine finger to orient through the Gln61 of Ras the nucleophilic water molecule. RapGAP contributes an aspar...
متن کاملUnraveling the mechanism of dual-specificity GAPs
Thank you for submitting your manuscript for consideration by The EMBO Journal. Please excuse the delay in getting back to you with a decision, due to restricted reviewer availabilities at this time at the turning of the years. We have now received the comments of three reviewers, which I am enclosing below. As you will, two referees find your results on the mechanism used by a dualspecificity ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2010
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2010.20